Lipnick R N, Tsokos G C, Magilavy D B
Department of Pediatrics, George Washington University Medical School, Washington, DC.
Rheum Dis Clin North Am. 1991 Nov;17(4):843-57.
Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease of childhood. Although the etiology remains unknown, immunoregulatory imbalances are thought to be important in the pathogenesis of JRA. Numerous immunologic abnormalities have been described in these patients, but it remains unclear which are fundamental to the pathogenesis of the disease and which are secondary. In this article, the authors review lymphocyte and lymphokine abnormalities in children with JRA with emphasis on the possible role of these immune abnormalities in the pathogenesis of JRA.
青少年类风湿性关节炎（JRA）是儿童时期最常见的风湿性疾病。尽管病因尚不清楚，但免疫调节失衡被认为在JRA的发病机制中起重要作用。这些患者已被描述出许多免疫异常情况，但仍不清楚哪些是该疾病发病机制的根本因素，哪些是次要因素。在本文中，作者回顾了JRA患儿的淋巴细胞和淋巴因子异常情况，重点关注这些免疫异常在JRA发病机制中的可能作用。
