Naughton Corina, Feely John, Bennett Kathleen
Department of Pharmacology and Therapeutics, Trinity College, Trinity Centres for Health Sciences St James Hospital, Dublin D 8, Ireland.
Fam Pract. 2007 Oct;24(5):475-80. doi: 10.1093/fampra/cmm044. Epub 2007 Aug 1.
Interventions to promote prescribing of preventive therapies in patients with cardiovascular disease (CVD) or diabetes have reported variable success.
(i) To evaluate the effect of prescribing feedback on GP practice using academic detailing compared to postal bulletin on prescribing of CVD preventive therapies in patients with CVD or diabetes at 3 and 6 months post intervention and (ii) to evaluate the intervention from a GP's perspective.
Volunteer GP practices (n = 98) were randomized to receive individualized prescribing feedback via academic detailing (postal bulletin plus outreach visit) (n = 48) or postal bulletin (n = 50). The proportion of CVD or diabetic patients on statins and antiplatelet agents/warfarin pre- and post-intervention was calculated for each GP practice. Multivariate regression with a random effects model was used to compare differences between the groups adjusting for GP clustering and confounding factors. beta-Coefficients and 95% confidence intervals (CIs) are presented.
There was a 3% increase in statin prescribing in CVD patients at 6 months post-intervention for both randomized groups, but there was no statistical difference between the groups (beta = 0.004; 95% CI = -0.01 to 0.02). Statin and antiplatelet/warfarin prescribing also increased in the diabetic population; there was no significant differences between the groups. GPs participating in the project expressed a high level of satisfaction with both interventions.
Prescribing of preventive therapies increased in both randomized groups over the study period. But academic detailing did not have an additional effect on changing prescribing over the postal bulletin alone.
旨在促进心血管疾病(CVD)或糖尿病患者预防性治疗药物处方开具的干预措施,其成效各异。
(i)评估与邮寄简报相比,学术指导形式的处方反馈对全科医生诊所开具CVD预防性治疗药物处方的影响,干预后3个月和6个月时针对CVD或糖尿病患者;(ii)从全科医生的角度评估该干预措施。
98家志愿参与的全科医生诊所被随机分为两组,一组通过学术指导(邮寄简报加外展访问)接受个性化处方反馈(n = 48),另一组接受邮寄简报(n = 50)。计算每家全科医生诊所干预前后使用他汀类药物和抗血小板药物/华法林的CVD或糖尿病患者比例。采用随机效应模型的多变量回归分析,比较两组之间的差异,并对全科医生聚类和混杂因素进行校正。呈现β系数和95%置信区间(CI)。
干预后6个月,两个随机分组中CVD患者的他汀类药物处方开具率均提高了3%,但两组之间无统计学差异(β = 0.004;95% CI = -0.01至0.02)。糖尿病患者中他汀类药物以及抗血小板药物/华法林的处方开具率也有所提高;两组之间无显著差异。参与该项目的全科医生对两种干预措施均表示高度满意。
在研究期间,两个随机分组中预防性治疗药物的处方开具率均有所提高。但仅学术指导相较于邮寄简报,在改变处方开具方面并无额外效果。