Nève P
Service de Médecine, Hôpital Erasme, Université Libre de Bruxelles.
Rev Med Brux. 1991 Dec;12(10):402-6.
Patients with proven recurrent venous or arterial thrombosis should be investigated for a predisposing cause corresponding to a hypercoagulable state. The latter is made up of two broad categories: the first consists of inherited thrombotic disorders; the second of a heterogeneous array of acquired clinical disorders, some of which are illustrated by clinical reports encountered in our department of internal medicine. Although the development and application of specific tests have provided valuable information about the pathogenesis of intravascular thromboses, these assays are currently able to provide aetiological diagnoses in fewer than 20 percent of young patients with recurrent venous thromboembolism.
确诊为复发性静脉或动脉血栓形成的患者,应针对与高凝状态相应的易患因素进行检查。高凝状态分为两大类:第一类由遗传性血栓形成障碍组成;第二类是一系列异质性的获得性临床疾病,其中一些在我们内科遇到的临床报告中有说明。尽管特定检测方法的开发和应用为血管内血栓形成的发病机制提供了有价值的信息,但目前这些检测方法在不到20%的复发性静脉血栓栓塞年轻患者中能够提供病因诊断。