Sjo O H, Lunde O C, Nygaard K, Sandvik L, Nesbakken A
Department of Gastrointestinal Surgery, Aker University Hospital, Oslo, Norway.
Colorectal Dis. 2008 Jan;10(1):33-40. doi: 10.1111/j.1463-1318.2007.01302.x. Epub 2007 Aug 2.
To evaluate survival and prognostic factors in a consecutive series of colon cancer patients from a defined city population in Norway.
All patients with adenocarcinoma of the colon diagnosed between 1993 and 2000 were registered prospectively. Five-year actuarial survival and 5-year relative survival rates were calculated. Cox regression analyses were used to study the effect of prognostic factors on survival.
In the study period 627 patients were admitted. Overall 5-year relative survival was 50% in females and 52% in males. Five-year relative survival in 410 (65%) patients operated with curative intent, was 74% for females and 79% for males. Tumour location in the transverse colon, splenic flexure and descending colon (OR = 1.8), emergency operation (OR = 1.7), TNM stage (OR = 1.8-2.9), blood transfusion of more than two units (OR = 1.8) and age (OR = 4.0-7.1) were independent negative prognostic factors.
Colon cancer located in the transverse and descending colon is associated with poor prognosis. Comparison of results from different centres is difficult due to selection and classification differences, and different methods used for calculation of survival.
评估挪威某特定城市连续一系列结肠癌患者的生存率及预后因素。
前瞻性登记1993年至2000年间诊断为结肠腺癌的所有患者。计算5年精算生存率和5年相对生存率。采用Cox回归分析研究预后因素对生存的影响。
在研究期间，共收治627例患者。总体而言，女性5年相对生存率为50%，男性为52%。410例（65%）接受根治性手术的患者中，女性5年相对生存率为74%，男性为79%。横结肠、脾曲和降结肠的肿瘤位置（比值比=1.8）、急诊手术（比值比=1.7）、TNM分期（比值比=1.8 - 2.9）、输注超过2单位血液（比值比=1.8）和年龄（比值比=4.0 - 7.1）是独立的不良预后因素。
横结肠和降结肠的结肠癌预后较差。由于选择和分类差异以及计算生存所用的不同方法，不同中心的结果比较困难。
