Novikova E G, Borisov V I, Dmitriev D G, Zel'vin B M, Karseladze A I, Shchitkov K G, Li A D
Sov Med. 1991(11):27-9.
The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a variant of drug therapy in multimodality treatment of ovarian cancer. Combination of intracavitary chemotherapy with a systemic one has the advantage of local and regional effect which is not inhibited by mediated action of the deposited cytostatics via the systemic blood flow. The method is indicated in residual tumor dissemination after cytoreductive surgery and ovarian cancer with ascites.
本文介绍了晚期卵巢癌腔内化疗联合植入细胞抑制剂的结果，以及实验、形态学、生化和药理学数据。腹腔内植入填充有环磷酰胺、5-氟尿嘧啶、阿霉素的微球可作为卵巢癌多模式治疗中药物治疗的一种方式。腔内化疗与全身化疗相结合具有局部和区域作用的优势，不会受到植入细胞抑制剂通过全身血流介导作用的抑制。该方法适用于减瘤手术后残留肿瘤播散和伴有腹水的卵巢癌。
