毛细胞白血病

Hairy cell leukemia.

作者信息

Swords Ronan, Giles Francis

机构信息

Department of Haematology, University College Hospital Galway, Galway, Ireland.

出版信息

Med Oncol. 2007;24(1):7-15. doi: 10.1007/BF02685898.

DOI:10.1007/BF02685898

PMID:17673807

Abstract

Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with "hairy" lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52 yr. Typically, patients with HCL respond well to purine analog-based therapy. The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions.

摘要

毛细胞白血病（HCL）是一种慢性B淋巴细胞增殖性疾病，其特征为全血细胞减少以及“毛细胞”淋巴细胞对网状内皮系统的不同程度浸润。HCL在男性中比女性更常见，诊断时的中位年龄为52岁。通常，HCL患者对基于嘌呤类似物的治疗反应良好。本综述的目的是阐述HCL在病理生理学、诊断、治疗及未来发展方向方面的现状。