Verma Susama, Cikurel Katia, Koralnik Igor J, Morgello Susan, Cunningham-Rundles Charlotte, Weinstein Zelig R, Bergmann Christine, Simpson David M
Department of Neurology, Mount Sinai Medical Center, New York, NY 10029, USA.
J Infect Dis. 2007 Sep 1;196(5):709-11. doi: 10.1086/520514. Epub 2007 Jul 13.
Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.
进行性多灶性白质脑病（PML）是一种通常致命的脑白质疾病，见于人类免疫缺陷病毒感染及其他免疫功能低下状态的患者。我们报告一例63岁真性红细胞增多症女性患者，其出现进行性局灶性神经功能缺损，脑部磁共振成像显示白质异常，活检证实为PML。她接受了5-羟色胺再摄取抑制剂米氮平治疗，诊断后2年多来神经功能保持稳定，脑病变消退。我们建议应对米氮平用于PML的治疗作进一步研究。
