正电子发射断层扫描在眼部附属器淋巴瘤分期及评估其对治疗反应中的价值。

Value of positron emission tomography in staging ocular adnexal lymphomas and evaluating their response to therapy.

作者信息

Gayed Isis, Eskandari M Farahnaz, McLaughlin Peter, Pro Barbara, Diba Roxana, Esmaeli Bita

机构信息

Department of Nuclear Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

出版信息

Ophthalmic Surg Lasers Imaging. 2007 Jul-Aug;38(4):319-25. doi: 10.3928/15428877-20070701-08.

DOI:10.3928/15428877-20070701-08

PMID:17674923

Abstract

BACKGROUND AND OBJECTIVE

An observational case series to assess the value of positron emission tomography (PET) in staging ocular adnexal lymphomas and evaluating their response to therapy.

PATIENTS AND METHODS

The clinical records of 16 consecutive patients with ocular adnexal lymphoma for whom pretreatment and posttreatment PET scans and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) scans were available were compared.

RESULTS

Pretreatment PET scans demonstrated fluorine 18-fluorodeoxyglucose (FDG) positive lesions in 15 orbits of 12 patients. In 1 patient with low-grade follicular lymphoma of the orbit, PET revealed an additional focus of lymphoma in the deltoid muscle that was missed on clinical examination and conventional radiography. All of the posttreatment PET scans showed complete resolution of FDG uptake, suggesting good response to therapy. However, posttreatment CT and MRI scans demonstrated residual masses in 3 patients.

CONCLUSIONS

PET is valuable for initial staging of ocular adnexal lymphomas and may be a good adjunct to conventional imaging in evaluation of response to therapy.

摘要

背景与目的

一项观察性病例系列研究，旨在评估正电子发射断层扫描（PET）在眼部附属器淋巴瘤分期及评估其对治疗反应中的价值。

患者与方法

比较了16例连续的眼部附属器淋巴瘤患者的临床记录，这些患者均有治疗前和治疗后的PET扫描以及相应的计算机断层扫描（CT）和磁共振成像（MRI）扫描资料。

结果

治疗前PET扫描显示，12例患者的15个眼眶中有氟-18-氟脱氧葡萄糖（FDG）阳性病变。在1例眼眶低度滤泡性淋巴瘤患者中，PET显示三角肌有一处淋巴瘤病灶，临床检查和传统放射检查均未发现。所有治疗后PET扫描均显示FDG摄取完全消退，提示对治疗反应良好。然而，治疗后CT和MRI扫描显示3例患者有残留肿块。