Ueno Takafumi, Yokoi Norihiko, Abe Satoshi, Watanabe Yoshihito
Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
J Inorg Biochem. 2007 Nov;101(11-12):1667-75. doi: 10.1016/j.jinorgbio.2007.06.025. Epub 2007 Jun 27.
Preparation of metal/protein hybrids is growing into important topics in the field of bioinorganic chemistry. X-ray crystal structure analyses of them provide direct information on unique interactions of metal cations or metal cofactors to understand and design enzymatic functions. In this mini review, the authors focus on the recent studies on the metal/protein hybrids concerning crystal structure analyses since 2002 and our related works. The precise structural determination promise us to deeply understand coordination chemistry in protein scaffold and shows intriguing suggestions on rational design and application use for biocatalysts, metal drugs and so on.
金属/蛋白质杂化物的制备正逐渐成为生物无机化学领域的重要课题。对它们的X射线晶体结构分析提供了有关金属阳离子或金属辅因子独特相互作用的直接信息，以了解和设计酶的功能。在这篇小型综述中，作者重点关注了自2002年以来有关金属/蛋白质杂化物晶体结构分析的最新研究以及我们的相关工作。精确的结构测定使我们能够深入理解蛋白质支架中的配位化学，并为生物催化剂、金属药物等的合理设计和应用提供有趣的建议。
