Baines S J, Blacklaws B A, McInnes E, McConnell I M
Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 0PQ, United Kingdom.
Vet Immunol Immunopathol. 2007 Oct 15;119(3-4):316-21. doi: 10.1016/j.vetimm.2007.06.007. Epub 2007 Jun 17.
Canine cutaneous histiocytoma (CCH) has been identified as a tumour of epidermal Langerhans cells (LCs) on the basis of immunophenotypic studies. Neoplastic Langerhans cells (CCH-LCs) were isolated from lesions of canine cutaneous histiocytoma. The CCH-LC cells expressed CD1b, CD11/18, CD45, MHC-I, and MHC-II. The CCH-LC cells were potent stimulators of the mixed leucocyte reaction (MLR) in vitro when compared to PBMCs from the tumour-bearing animals. This provides evidence that the neoplastic cells in CCH have functional as well as immunophenotypic characteristics of Langerhans cells.
基于免疫表型研究，犬皮肤组织细胞瘤（CCH）已被确定为一种表皮朗格汉斯细胞（LCs）肿瘤。从犬皮肤组织细胞瘤病变中分离出肿瘤性朗格汉斯细胞（CCH-LCs）。CCH-LC细胞表达CD1b、CD11/18、CD45、MHC-I和MHC-II。与来自荷瘤动物的外周血单核细胞（PBMCs）相比，CCH-LC细胞在体外是混合淋巴细胞反应（MLR）的有效刺激物。这提供了证据表明CCH中的肿瘤细胞具有朗格汉斯细胞的功能以及免疫表型特征。
