[单硝基酚作用下大鼠肝脏氧化与磷酸化过程紊乱的特点]
[Peculiarities of disturbances in oxidation and phosphorylation processes in rat liver under the effect of mononitrophenols].
作者信息
Kolodib F A, Vasilenko N M
出版信息
Ukr Biokhim Zh. 1976 Jan-Feb;48(1):30-3.
PMID:176756
Abstract
It is determined that ortho- and n-nitrophenol introduced into the stomach (0.80 and 0.11 g/kg, respectively) inhibit the activity of cytochrome oxydase (by 21% at an average), cause an increase in the content of NADH (by 35 and 27%) and a decrease in ATP (by 38 and 36%, respectively), split the oxidation and phosphorylation processes in the rat liver tissue. The content of NAD+, AMP and ADP, lactate, the activity of K+, Na+-ATPase and lactate dehydrogenase do not change.
摘要
经测定，引入胃内的邻硝基苯酚和间硝基苯酚（分别为0.80和0.11 g/kg）抑制细胞色素氧化酶的活性（平均抑制21%），导致NADH含量增加（分别增加35%和27%）以及ATP减少（分别减少38%和36%），使大鼠肝脏组织中的氧化和磷酸化过程发生解离。NAD⁺、AMP和ADP的含量、乳酸含量、K⁺、Na⁺-ATP酶和乳酸脱氢酶的活性均未改变。
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