Jenkins K A, Bean A G D, Lowenthal J W
CSIRO Livestock Industries, Australian Animal Health Laboratories, Geelong, Australia.
Cytogenet Genome Res. 2007;117(1-4):207-12. doi: 10.1159/000103181.
Viral diseases pose a significant threat to the poultry industry. However, there is currently a lack of antivirals and suitable vaccine adjuvants available to the poultry industry to combat this problem. The innate immune system is now recognised to be essential in the response to viral infection. However, in contrast to mammals, the innate immune response in chickens is relatively uncharacterised. The release of the full chicken genome sequence has accelerated the identification of genes involved in the immune response. The characterisation of these genes, including Toll-like receptors and cytokines has led to the identification of potential alternate antivirals and adjuvants.
病毒性疾病对家禽业构成重大威胁。然而，目前家禽业缺乏抗病毒药物和合适的疫苗佐剂来应对这一问题。现在人们认识到先天免疫系统在应对病毒感染中至关重要。然而，与哺乳动物不同，鸡的先天免疫反应相对缺乏特征描述。鸡全基因组序列的公布加速了参与免疫反应基因的鉴定。对这些基因的特征描述，包括Toll样受体和细胞因子，已促成了潜在替代抗病毒药物和佐剂的鉴定。
