Dahlberg James E, Lund Elsebet
Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.
Sci STKE. 2007 May 22;2007(387):pe25. doi: 10.1126/stke.3872007pe25.
The innate immune response can be initiated by the binding of various pathogen-associated compounds or cytokines to receptors on the surfaces of dendritic cells. These interactions result in the activation of many genes and gene products. Several different pathways converge to raise the abundance of specific microRNAs (miRNAs). In particular, activation of the transcription factors AP-1 and NF-kappaB results in an increase in the amount of miR-155. High levels of this miRNA are associated with several types of cancer. However, the mRNAs that may be targeted by miR-155 in the innate immune response remain to be determined.
先天性免疫反应可由多种病原体相关化合物或细胞因子与树突状细胞表面受体的结合引发。这些相互作用导致许多基因和基因产物的激活。几种不同的途径汇聚在一起，以提高特定微小RNA（miRNA）的丰度。特别是，转录因子AP-1和核因子κB的激活导致miR-155数量增加。这种miRNA的高水平与几种类型的癌症相关。然而，在先天性免疫反应中可能被miR-155靶向的mRNA仍有待确定。
