Perdereau F, Faucher S, Jeammet P, Godart N-T
Département de Psychiatrie, Institut Mutualiste Montsouris, 42 boulevard Jourdan, 75014 Paris, France.
Encephale. 2007 Mar-Apr;33(2):144-55. doi: 10.1016/s0013-7006(07)91544-4.
In the literature, no review concerning the family comorbidity of mood and anxiety disorders of anorexic subjects exists. However, this data can be important for the comprehension of this disorder and for the assumption of responsibility.
We conducted a critical literature review on studies assessing the prevalence of anxiety disorders (AD) and mood disorders in relatives of anorexia nervosa (AN) subjects. In the first part, we discuss methodological issues relevant to these comorbidity studies. In the second part, taking into account the methodological considerations raised, we summarise the findings of these studies.
We performed a manual and computerised search (Medline) for all published studies on the frequency of MD and AD in AN relatives and MD or AD, limiting our search to the 1980-2002 period, in order to get sufficiently homogeneous diagnostic criteria for both categories of disorders (most often RDC, DSM III, DSM III-R, or DSM IV criteria).
We review methodological issues regarding population sources, general methodological procedures, diagnostic criteria for AN, MD and AD, diagnostic instruments, age of subjects and course of the eating disorder.
We discuss the results taking into account the methodological problems observed. We give implications for reviewing the results of published studies and planning future research.
在文献中，尚无关于厌食症患者情绪和焦虑障碍家族共病情况的综述。然而，这些数据对于理解该疾病以及承担责任而言可能很重要。
我们对评估神经性厌食症（AN）患者亲属中焦虑障碍（AD）和情绪障碍患病率的研究进行了批判性文献综述。在第一部分，我们讨论与这些共病研究相关的方法学问题。在第二部分，考虑到所提出的方法学考量，我们总结这些研究的结果。
我们通过手工和计算机检索（Medline），查找所有已发表的关于AN亲属中MD和AD发生频率以及MD或AD的研究，将检索范围限制在1980 - 2002年期间，以便为这两类障碍获得足够统一的诊断标准（最常用的是RDC、DSM III、DSM III - R或DSM IV标准）。
我们综述了关于人群来源、一般方法学程序、AN、MD和AD的诊断标准、诊断工具、研究对象年龄以及饮食障碍病程等方面的方法学问题。
我们结合所观察到的方法学问题来讨论结果。我们阐述了对已发表研究结果进行综述以及规划未来研究的启示。
