S-苯并恶唑基糖苷的通用合成方法及活化机制
Versatile synthesis and mechanism of activation of S-benzoxazolyl glycosides.
作者信息
Kamat Medha N, Rath Nigam P, Demchenko Alexei V
机构信息
Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.
出版信息
J Org Chem. 2007 Aug 31;72(18):6938-46. doi: 10.1021/jo0711844. Epub 2007 Aug 4.
Abstract
As a part of a program for developing new efficient procedures for stereoselective glycosylation, a range of S-benzoxazolyl (SBox) glycosides have been synthesized. The mechanistic aspects of the SBox moiety activation for glycosylation via a variety of conceptually different pathways in the presence of thiophilic, electrophilic, or metal-based promoters have been investigated.
摘要
作为开发新型高效立体选择性糖基化方法计划的一部分，已合成了一系列S-苯并恶唑基（SBox）糖苷。研究了在亲硫、亲电或金属基促进剂存在下，通过各种概念上不同的途径使SBox部分活化以进行糖基化的机理。
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