Shu Yafei, Chen Meihang, Lu Daowang, Zhou Zengyan, Yu Jianhong, Hu Xiaoling, Yang Jiaqin, Li Aiqin, Liu Jianglong, Luo Hairong
Colleges of Material and Chemistry Engineering, Tongren University, Tongren, China.
Front Chem. 2022 May 19;10:910710. doi: 10.3389/fchem.2022.910710. eCollection 2022.
A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized, and the structure of them was verified by spectroscopy of NMR and HRMS, and antifungal and antibacterial activities of them were screened. The results showed that the newly synthesized compounds had good antifungal activities. Among them, Ⅲ16, Ⅲ17, and Ⅲ19 exhibited satisfactory activities against , with EC values of 5.87, 4.98, and 6.17 μg/ml, respectively, which were similar to those of dimethomorph (5.52 μg/ml). Meanwhile, the title compounds also possessed certain antibacterial activities.
合成了一系列含1,3,4-噻二唑部分的新型半乳糖苷衍生物，通过核磁共振光谱和高分辨质谱对其结构进行了确证，并对它们的抗真菌和抗菌活性进行了筛选。结果表明，新合成的化合物具有良好的抗真菌活性。其中，Ⅲ16、Ⅲ17和Ⅲ19对……表现出令人满意的活性，其EC值分别为5.87、4.98和6.17μg/ml，与烯酰吗啉（5.52μg/ml）的EC值相似。同时，标题化合物也具有一定的抗菌活性。
