Mota A, Fonseca G, Rebelo I, Crespo M E
Unidade de Endocrinologia Pediátrica do Hospital de D. Estefânia, Lisboa.
Acta Med Port. 1991 Jul-Aug;4(4):188-90.
Before the age of 8 in females and 9 in males, the presence of pubic hair can be the first sign of a gonadal or adrenal disease. In order to identify the late onset type of congenital adrenal hyperplasia in premature pubescence, we did the adrenal short stimulation test with Synacthen, on 30 children. Five girls and one boy showed a 21-hydroxylase deficiency, in which the seric 17-OH Progesterone at 60 minutes is 28.8 +/- 15.2 ng/ml, being in a control group 2.30 +/- 0.8 ng/ml [p less than 0.01]. The 20% incidence we have found, justifies the testing of every premature pubescent child.
在女性8岁、男性9岁之前,出现阴毛可能是性腺或肾上腺疾病的首个迹象。为了鉴别青春期早熟型先天性肾上腺皮质增生症,我们对30名儿童进行了用辛纳科(合成促肾上腺皮质激素)的肾上腺短刺激试验。5名女孩和1名男孩表现出21-羟化酶缺乏,其中60分钟时血清17-羟孕酮为28.8±15.2纳克/毫升,而对照组为2.30±0.8纳克/毫升[P<0.01]。我们发现的20%的发病率表明对每个青春期早熟儿童进行检测是合理的。