Battista G, Costantini Adele Seniori, Gorini G, Orsi D, Paredes I, Miceli G B, De Vuono Giulia, Peccetti Valeria
Università degli Studi, Dipartimento di Farmacologia "G. Segre", Siena.
Med Lav. 2007 Jul-Aug;98(4):289-95.
The aim of this study was to investigate mortality of a cohort of 1,767 male workers employed in a sugar refinery plant located in the Province of Arezzo, Italy, where asbestos had been used from the 1960's for the insulation of thermohydraulic systems and for furnaces. In 1987-88 workers removed the asbestos-cement insulation from the plant.
The cohort was composed by male workers who were employed in the plant between 1 March 1962 and 1 February 1996, and had worked for at least 2 months. Follow-up started on 1 March 1962, and ended on 31 May, 2003. The population mortality for Tuscany Region was used as the reference. The relative risk was estimated by Standardized Mortality Ratio (SMR) and the confidence intervals were calculated at a 95% level (95% CI).
The majority of workers were employed during the summer only. Significant decreases in mortality were observed for overall mortality (SMR = 78; 95% CI = 69-88), all cancers (SMR = 80; 95% CI = 65-97), cardiovascular diseases (SMR = 64; 95% CI = 50-81), lung cancer (SMR = 66; 95% CI = 43-98), and gastrointestinal diseases (SMR = 53; 95% CI = 26-98). Non-significant increases were observed for kidney cancer (SMR = 229; 95% CI = 92-472), and diseases of the nervous system (SMR = 155; 95% CI = 71-294). Kidney cancer mortality for workers employed for > = 5 years was significantly higher (SMR = 508; 95% CI = 105-1485).
Mortality for asbestos-related diseases did not show any increase. The higher kidney cancer mortality for workers employed for > = 5 years could be due to exposures to various carcinogens, that occurred not only in the sugar refinery plant, given that the workers were seasonal and did other jobs during the rest of the year. Asbestos-related deaths could occur in the future among some workers who in 1987-88 were employed on the removal of asbestos-cement insulation from the plant.
本研究旨在调查意大利阿雷佐省一家糖厂雇佣的1767名男性工人的死亡率，该糖厂自20世纪60年代起使用石棉对热液压系统和熔炉进行绝缘处理。1987 - 1988年，工人们拆除了该厂的石棉水泥绝缘材料。
该队列由1962年3月1日至1996年2月1日期间受雇于该厂且工作至少2个月的男性工人组成。随访始于1962年3月1日，结束于2003年5月31日。以托斯卡纳地区的总体死亡率作为参考。通过标准化死亡比（SMR）估计相对风险，并计算95%水平的置信区间（95%CI）。
大多数工人仅在夏季受雇。总体死亡率（SMR = 78；95%CI = 69 - 88）、所有癌症（SMR = 80；95%CI = 65 - 97）、心血管疾病（SMR = 64；95%CI = 50 - 81）、肺癌（SMR = 66；95%CI = 43 - 98）和胃肠道疾病（SMR = 53；95%CI = 26 - 98）的死亡率均显著降低。肾癌（SMR = 229；95%CI = 92 - 472）和神经系统疾病（SMR = 155；95%CI = 71 - 294）的死亡率有不显著升高。工作≥5年的工人肾癌死亡率显著更高（SMR = 508；95%CI = 105 - 1485）。
与石棉相关疾病的死亡率未出现任何升高。工作≥5年的工人肾癌死亡率较高可能是由于接触了多种致癌物，鉴于这些工人是季节性的，且在一年中的其他时间从事其他工作，所以接触不仅发生在糖厂。1987 - 1988年参与该厂石棉水泥绝缘材料拆除工作的一些工人未来可能会出现与石棉相关的死亡。
