Akosah Kwame O, McHugh Vicki L, Mathiason Michelle A, Kulkarni Amit, Barnhart Sharon I
Gundersen Lutheran Health System, La Crosse, WI, USA.
J Cardiometab Syndr. 2006 Summer;1(3):173-7. doi: 10.1111/j.1559-4564.2006.05780.x.
There are questions concerning the validity of the metabolic syndrome as a diagnostic entity and whether the syndrome predicts coronary heart disease (CHD) better than global risk stratification. The use of the metabolic syndrome as a potential adjunct to improve global risk stratification has received less attention. The authors evaluated the relationship between the metabolic syndrome and cardiovascular disease compared with coronary heart disease equivalent. Two hundred thirty-six subjects undergoing elective coronary angiography had bilateral carotid ultrasound studies and global risk scores calculated. Mean total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglyceride values were normal. The metabolic syndrome was associated with carotid atherosclerosis (odds ratio, 2.3; confidence interval, 1.2-4.2), coronary disease (odds ratio, 2.9; confidence interval, 1.6-5.4), and future cardiovascular events. Rates for future events and coronary and carotid atherosclerosis were similar for subjects with the metabolic syndrome compared with coronary heart disease equivalent. Combined, the two conditions identified 70% of subjects who developed events. The metabolic syndrome is associated with cardiovascular disease and provides additive information to clinical risk stratification.
关于代谢综合征作为一种诊断实体的有效性以及该综合征是否比整体风险分层能更好地预测冠心病（CHD）存在一些问题。将代谢综合征作为改善整体风险分层的潜在辅助手段受到的关注较少。作者评估了代谢综合征与心血管疾病之间的关系，并与冠心病等效情况进行了比较。236名接受择期冠状动脉造影的受试者进行了双侧颈动脉超声检查并计算了整体风险评分。总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇以及甘油三酯的平均水平均正常。代谢综合征与颈动脉粥样硬化（比值比，2.3；置信区间，1.2 - 4.2）、冠心病（比值比，2.9；置信区间，1.6 - 5.4）以及未来心血管事件相关。与冠心病等效情况相比，代谢综合征患者未来事件以及冠状动脉和颈动脉粥样硬化的发生率相似。这两种情况综合起来可识别出70%发生事件的受试者。代谢综合征与心血管疾病相关，并为临床风险分层提供补充信息。
