Sedov V M, Andreev D Yu, Smirnova T D, Paramonov B A, Enkina T N, Sominina A A, Kiselev O I, Suissi Yu Yu, Lebedev L V
I. P. Pavlov Sankt-Peterburg State Medical University, Sankt-Peterburg, Russia.
Angiol Sosud Khir. 2007;13(1):65-75.
This paper analyzes the results of cell therapy carried out during multimodality treatment of 23 patients with trophic ulcers of the lower limbs because of varicosity and postthrombotic disease. Twenty-five patients were entered into the control group provided the modern wound dressings Suprasorb. It has been demonstrated that cell therapy applying fibroblasts, strain 11 00/14, noticeably upgrades the treatment efficacy. Ulcer healing was attained in all the patients of the basic group. The times of epithelialization averaged 1.5 week for varicose and 3.2 weeks for postthrombotic ulcers. In the control group, the healing of varicose trophic ulcers was recorded in 86% and of postthrombotic ulcers in 78% of patients. The times of healing averaged 3.6 and 3.9 months respectively, Cell therapy as part of multimodality treatment of trophic venous ulcers excels the modern wound dressings as regards the efficacy.
本文分析了对23例因静脉曲张和血栓后疾病导致下肢营养性溃疡患者进行多模式治疗期间开展细胞治疗的结果。25例患者进入对照组，使用现代伤口敷料Suprasorb。结果表明，应用11 00/14株成纤维细胞的细胞治疗显著提高了治疗效果。基础组所有患者的溃疡均愈合。静脉曲张性溃疡的上皮化时间平均为1.5周，血栓后溃疡为3.2周。在对照组中，86%的静脉曲张性营养性溃疡患者和78%的血栓后溃疡患者实现愈合。愈合时间平均分别为3.6个月和3.9个月。细胞治疗作为营养性静脉溃疡多模式治疗的一部分，在疗效方面优于现代伤口敷料。
