Yasukawa Masako, Yasukawa Ken'ichi, Kamiizumi You, Yokoyama Ryouji
Department of Anesthesiology, Iwamizawa Municipal General Hospital, 9-Jo Nishi-7 Iwamizawa, Hokkaido 068-8555, Japan.
J Anesth. 2007;21(3):420-3. doi: 10.1007/s00540-007-0528-8. Epub 2007 Aug 1.
This case report series describes eight patients (four patients with pancreatic carcinoma, one patient with hepatocellular carcinoma, one patient with gastric and rectal carcinoma, one with sigmoid colon cancer, and one with rectal cancer), whose abdominal cancer pain was treated with intravenous phentolamine infusion at 80 mg x day(-1) for 2 days. All but one of the patients had already been treated with opioids. All eight patients complained of severe abdominal pain; in five patients the pain radiated to the back, and there was associated anal pain in two patients. Analgesia was achieved in three patients; pain alleviation was obtained in four patients, but was not sustained in two of these four patients; and the treatment in one patient could not be judged for efficacy because epidural morphine was used together with the phentolamine. Adverse effects of phentolamine were tachycardia and/or hypotension.
本病例报告系列描述了8例患者（4例胰腺癌患者、1例肝细胞癌患者、1例胃和直肠癌患者、1例乙状结肠癌患者以及1例直肠癌患者），他们的腹部癌痛通过静脉输注酚妥拉明80mg/天，持续2天进行治疗。除1例患者外，其他所有患者均已接受过阿片类药物治疗。所有8例患者均主诉有严重的腹痛；5例患者疼痛放射至背部，2例患者伴有肛门疼痛。3例患者实现了镇痛；4例患者疼痛得到缓解，但其中2例患者的缓解未持续；1例患者的治疗效果无法判断，因为酚妥拉明与硬膜外吗啡联合使用。酚妥拉明的不良反应为心动过速和/或低血压。
