Piekarska Anna, Jozefowicz-Korczynska Magdalena, Wojcik Kamila, Berkan Ewa
Department of Infectious Diseases and Hepatology, Medical University of Lodz, Poland.
Int J Audiol. 2007 Jul;46(7):345-50. doi: 10.1080/14992020701261413.
Sudden hearing loss is a very rare complication of interferon-alpha treatment. At this time, hearing loss in patients treated with pegylated interferon and ribavirin has only been described in two reports. We present a case of a 27-year-old patient who was diagnosed with Turner syndrome, treated for hepatitis C with pegylated interferon and ribavirin, and suffered from hearing loss during the 10th week of treatment. Audiometric examination revealed a bilateral sensorineural hearing loss (SNHL). Auditory brainstem response (ABR) measures confirmed the diagnosis. We decided to comply with the patient's request to continue therapy, which only led to slight further deterioration of the patient's hearing ability. However, 18 months after the end of therapy a follow-up audiometric examination disclosed a bilateral SNHL.
突发性听力损失是α-干扰素治疗非常罕见的并发症。目前，聚乙二醇化干扰素联合利巴韦林治疗的患者出现听力损失仅有两篇报道。我们报告一例27岁诊断为特纳综合征的患者，接受聚乙二醇化干扰素联合利巴韦林治疗丙型肝炎，在治疗第10周时出现听力损失。听力检查显示双侧感音神经性听力损失（SNHL）。听觉脑干反应（ABR）检测确诊。我们决定依从患者继续治疗的要求，但这仅导致患者听力能力轻微进一步恶化。然而，治疗结束18个月后的随访听力检查显示双侧SNHL。
