Ford C H, Richardson V J, Pushpanathan C, Ali S K
Oncology Research, Department of Surgery, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada.
Anticancer Res. 1991 Sep-Oct;11(5):1855-62.
The toxicity of the intensely potent anthracycline 3'deamino-3'-(3-cyano-4-morpholinyl)doxorubicin (MRA-CN) has been evaluated in nude mice bearing human colonic cancer xenografts. In addition to dose related toxicity manifested as weight loss and effects on the haematology profile, we obtained evidence of cardiotoxicity with MRA-CN, which has not been reported previously. Even a single dose of 0.012 mg kg-1 could induce significant myocardial changes as seen by electron microscopy. Our results suggest that nude mice bearing human tumour xenografts may offer a very sensitive model for the evaluation of anthracycline induced cardiomyopathy. In view of the potential of MRA-CN in cancer treatment, these results need to be confirmed and extended.
强效蒽环类药物3'-脱氨基-3'-(3-氰基-4-吗啉基)阿霉素(MRA-CN)的毒性已在携带人结肠癌异种移植瘤的裸鼠中进行了评估。除了表现为体重减轻和对血液学指标有影响的剂量相关毒性外，我们还获得了MRA-CN具有心脏毒性的证据，这在以前尚未见报道。即使单次剂量为0.012 mg kg-1，通过电子显微镜也可观察到明显的心肌变化。我们的结果表明，携带人肿瘤异种移植瘤的裸鼠可能为评估蒽环类药物诱导的心肌病提供一个非常敏感的模型。鉴于MRA-CN在癌症治疗中的潜力，这些结果需要得到证实和扩展。
