Zhang Yong, Yang Zhaojuan, Wu Ji
School of Life Science and Biotechnology, Shanghai Jiao Tong University, China.
FEBS J. 2007 Sep;274(17):4349-59. doi: 10.1111/j.1742-4658.2007.05980.x. Epub 2007 Aug 3.
The mammalian preimplantation embryo is a critical and unique stage in embryonic development. This stage includes a series of crucial events: the transition from oocyte to embryo, the first cell divisions, and the establishment of cellular contacts. These events are regulated by multiple signal-transduction pathways. In this article we describe patterns of stage-specific expression in several signal-transduction pathways and try to give a profile of the signaling transduction network in preimplantation development of mammalian embryo.
哺乳动物植入前胚胎是胚胎发育过程中的一个关键且独特的阶段。这个阶段包括一系列关键事件：从卵母细胞到胚胎的转变、首次细胞分裂以及细胞间接触的建立。这些事件由多种信号转导途径调控。在本文中，我们描述了几种信号转导途径中阶段特异性表达的模式，并试图勾勒出哺乳动物胚胎植入前发育过程中信号转导网络的概况。
