Lensen Gerda, Jungbauer Frank, Gonçalo Margarida, Coenraads Pieter Jan
Department of Dermatology and Academic Center for Occupation and Health, University Medical Center Groningen, University of Groningen, NL-9700 RB Groningen, The Netherlands.
Contact Dermatitis. 2007 Sep;57(3):181-6. doi: 10.1111/j.1600-0536.2007.01196.x.
Chlorothalonil (tetrachloro-1,3-benzenedicarbonitrile, CAS 1897-45-6) is a pesticide that has been on the market for many years. It is used as a fungicide in agriculture, horticulture, and floriculture; as a wood preservative; and in paint. We report an epidemic of airborne irritant contact dermatitis, conjunctivitis, and upper airway complaints among seamstresses in a Portuguese trailer tent factory, which we attribute to chlorothalonil. All exposed workers had work-related skin symptoms. After patch testing, we showed that none of these were of allergic origin. Instead of allergic reactions, we noticed a delayed type of irritation after 72 hr to chlorothalonil and to the textile extracts containing high concentrations of chlorothalonil. Although allergic and irritant contact dermatitis from chlorothalonil has been described before, this is, as far as we know, the first time that a delayed type of dermatitis, conjunctivitis, and upper airway irritation after exposure to chlorothalonil in tent-cloth is described.
百菌清（四氯-1,3-苯二甲腈，CAS 1897-45-6）是一种已在市场上销售多年的农药。它在农业、园艺和花卉栽培中用作杀菌剂；用作木材防腐剂；并用于油漆中。我们报告了葡萄牙一家拖车帐篷工厂的女裁缝中发生的空气传播刺激性接触性皮炎、结膜炎和上呼吸道不适的疫情，我们将其归因于百菌清。所有暴露的工人都有与工作相关的皮肤症状。经过斑贴试验，我们发现这些症状均非过敏所致。与过敏反应不同，我们注意到在接触百菌清和含有高浓度百菌清的纺织品提取物72小时后出现了迟发型刺激反应。虽然之前已经描述过百菌清引起的过敏性和刺激性接触性皮炎，但据我们所知，这是首次描述在帐篷布中接触百菌清后出现迟发型皮炎、结膜炎和上呼吸道刺激反应。
