Zai Gwyneth, Mundo Emanuela, Strauss John, Wong Gregory W H, Kennedy James L
Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Ontario, Canada.
Bipolar Disord. 2007 Aug;9(5):521-5. doi: 10.1111/j.1399-5618.2007.00416.x.
Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of bipolar disorder (BPD). Moreover, increasing BDNF production might be one of the mechanisms involved in the alleviation of depression and aggravation of mania in antidepressant treatment.
Thus, we hypothesized that a genetic variant within the BDNF gene might influence susceptibility to antidepressant-induced mania, as has been suggested previously.
We performed a case-control study to test for allelic frequency and genotype distribution differences across six BDNF polymorphisms between 27 patients with antidepressant-induced mania (IM+) and 29 patients without antidepressant-induced mania (IM-).
We did not observe any significant difference in either allelic or genotype frequencies between the two groups.
Our results did not support the BDNF link to mania hypothesis proposed previously. However, a larger sample would allow for greater power to determine smaller effects of the BDNF gene in antidepressant-induced mania.
脑源性神经营养因子（BDNF）在调节突触可塑性以及多个神经递质系统的神经递质释放中发挥重要作用。近期研究表明，BDNF在双相情感障碍（BPD）的发病机制中起作用。此外，增加BDNF的产生可能是抗抑郁治疗中缓解抑郁和加重躁狂所涉及的机制之一。
因此，正如之前所提示的，我们假设BDNF基因内的一个基因变异可能影响对抗抑郁药诱发躁狂的易感性。
我们进行了一项病例对照研究，以检测27例抗抑郁药诱发躁狂患者（IM+）和29例无抗抑郁药诱发躁狂患者（IM-）之间6种BDNF多态性的等位基因频率和基因型分布差异。
我们未观察到两组之间在等位基因或基因型频率上有任何显著差异。
我们的结果不支持先前提出的BDNF与躁狂相关的假说。然而，更大的样本量将使我们有更大的能力来确定BDNF基因在抗抑郁药诱发躁狂中的较小作用。
