Fauser S, Bast T, Altenmüller D-M, Schulte-Mönting J, Strobl K, Steinhoff B J, Zentner J, Schulze-Bonhage A
Epilepsy Centre, University of Freiburg, Breisacher Str 64, 79106 Freiburg, Germany.
J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):103-5. doi: 10.1136/jnnp.2007.116038. Epub 2007 Aug 6.
A total of 120 patients with histologically proven focal cortical dysplasias (FCD) were retrospectively analysed for prognostic factors for successful epilepsy surgery. Multivariate data analyses showed that older age at epilepsy surgery, occurrence of secondarily generalised seizures and a multilobar extent of the dysplasia were significant negative predictors. In univariate analyses, longer duration of epilepsy, need for intracranial EEG recordings and incomplete resection of the FCD were factors which significantly reduced the chance of becoming seizure free. Histological subtype of the FCD and age at epilepsy onset had no significant predictive value. These findings strongly suggest early consideration of epilepsy surgery in FCD patients.
对120例经组织学证实的局灶性皮质发育不良（FCD）患者进行回顾性分析，以确定癫痫手术成功的预后因素。多变量数据分析显示，癫痫手术时年龄较大、继发全身性发作的发生以及发育异常的多叶范围是显著的阴性预测因素。单变量分析中，癫痫病程较长、需要进行颅内脑电图记录以及FCD切除不完全是显著降低无癫痫发作几率的因素。FCD的组织学亚型和癫痫发作起始年龄没有显著的预测价值。这些发现强烈建议对FCD患者尽早考虑癫痫手术。
