Antonchik A V, Zhabinskiĭ V N, Khripach V A
Bioorg Khim. 2007 May-Jun;33(3):297-309.
The structural peculiarities of the most widespread oxysterols, the products of oxidative transformations of cholesterol are discussed. The transformations proceed with the participation of enzymatic systems of the body or as a result of various nonenzymatic reactions. The pathways of their formation from cholesterol are also considered. The role of oxysterols in the maintenance of cholesterol homeostasis and in the development of atherosclerosis is reviewed. The possibility of using oxysterols as markers of pathological processes is demonstrated.
本文讨论了最常见的氧化甾醇的结构特点，氧化甾醇是胆固醇氧化转化的产物。这些转化过程在体内酶系统的参与下进行，或是各种非酶反应的结果。文中还考虑了它们从胆固醇形成的途径。综述了氧化甾醇在维持胆固醇稳态和动脉粥样硬化发展中的作用。证明了使用氧化甾醇作为病理过程标志物的可能性。
