基线HIV-1型共受体嗜性可预测疾病进展。
Baseline HIV type 1 coreceptor tropism predicts disease progression.
作者信息
Daar Eric S, Kesler Karen L, Petropoulos Christos J, Huang Wei, Bates Michael, Lail Alice E, Coakley Eoin P, Gomperts Edward D, Donfield Sharyne M
机构信息
Los Angeles Biomedical Research Institute at Harbor-University of California-Los Angeles (UCLA) Medical Center and the David Geffen School of Medicine at UCLA, Torrance, USA.
出版信息
Clin Infect Dis. 2007 Sep 1;45(5):643-9. doi: 10.1086/520650. Epub 2007 Jul 20.
BACKGROUND
Human immunodeficiency virus type 1 (HIV-1) coreceptor tropism, the ability of the virus to enter cells via CCR5 or CXCR4, is a viral characteristic mediated by the envelope gene. The impact of coreceptor tropism on the natural history of HIV-1 infection has not been fully explored.
METHODS
Coreceptor tropism was measured using a recombinant virus single-cycle assay on plasma specimens obtained at baseline from 126 children and adolescents in the Hemophilia Growth and Development Study cohort who were enrolled from 1989 through 1990 and underwent follow-up through 1997.
RESULTS
Detectable CXCR4-using virus at baseline was associated with a lower baseline CD4(+) T cell count and a higher plasma HIV-1 RNA level. In addition, it independently predicted a greater decrease in CD4(+) T cell count over time (P<.001) and was associated with a 3.8-fold increased risk of progression to clinical AIDS.
CONCLUSIONS
This study demonstrates that coreceptor tropism, as assessed by this single-cycle assay, independently influences the natural history of HIV-1 disease.
背景
人类免疫缺陷病毒1型（HIV-1）共受体趋向性，即病毒通过CCR5或CXCR4进入细胞的能力，是一种由包膜基因介导的病毒特性。共受体趋向性对HIV-1感染自然史的影响尚未得到充分研究。
方法
使用重组病毒单循环试验对1989年至1990年入组血友病生长与发育研究队列并随访至1997年的126名儿童和青少年基线时采集的血浆标本进行共受体趋向性检测。
结果
基线时可检测到的使用CXCR4的病毒与较低的基线CD4(+) T细胞计数和较高的血浆HIV-1 RNA水平相关。此外，它独立预测随着时间推移CD4(+) T细胞计数下降幅度更大（P<.001），并与进展为临床艾滋病的风险增加3.8倍相关。
结论
本研究表明，通过这种单循环试验评估的共受体趋向性独立影响HIV-1疾病的自然史。
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