[口腔疣状癌和口腔鳞状细胞癌中的基因表达谱变化]
[Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma].
作者信息
Tang Zhan-gui, Zhao Su-ping, Zhang Lei, Li Xiao-ling
机构信息
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Apr;42(4):229-30.
OBJECTIVE
To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC).
METHODS
cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined.
RESULTS
Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC.
CONCLUSIONS
The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.
目的
确定人类口腔疣状癌（OVC）与口腔鳞状细胞癌（OSCC）之间基因表达的差异。
方法
采用cDNA芯片检测4例OVC和4例OSCC癌组织的mRNA。经生物信息学进行图谱扫描和处理后，检测这两种病变的基因表达情况。
结果
使用BioStarH - 40图谱，发现593个基因表达不同。不同基因的比例为15.2%，其中OVC组织中283个基因的表达增加（59个基因显著增加），310个基因的表达减少（98个基因显著减少），与OSCC相比。
结论
OVC和OSCC的基因表达不同，这可能导致这两种病变的生物学行为不同。
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