[氟中毒对大鼠切牙中碱性成纤维细胞生长因子表达的影响]
[Effect of fluorosis on the expression of basic fibroblast growth factor in rat incisors].
作者信息
Liu Hui, Wang Qiang, Zhu Feng, Luo Ping-ping, Liu Tian-lin, Wei Xiao-ling
机构信息
Department of Cariology and Endodontology, School of Stomatology, Tongji University, Shanghai 200072, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Apr;42(4):242-4.
OBJECTIVE
To investigate the effects of overdose fluoride on the expression of basic fibroblast growth factor (bFGF) in rat incisors.
METHODS
Twenty Wistar rats were randomly divided into 2 groups: group I (control group) distilled water was given; group II (experimental group) 100 mg/L NaF was given. The rats were killed at the end of 8 th week. Immunohistochemical staining was used to study the expression of bFGF in rat incisors.
RESULTS
Immunohistochemical results demonstrated the presence of bFGF in ameloblasts, odontoblasts of rat incisors. The expression of bFGF was reduced in group II (P < 0.01).
CONCLUSIONS
Overdose fluoride inhibits the expression of bFGF and affects the interaction between dental epithelium and dental mesenchyme, which leads to the enamel demineralization.
目的
研究过量氟对大鼠切牙中碱性成纤维细胞生长因子（bFGF）表达的影响。
方法
将20只Wistar大鼠随机分为2组：Ⅰ组（对照组）给予蒸馏水；Ⅱ组（实验组）给予100mg/L氟化钠。在第8周结束时处死大鼠。采用免疫组织化学染色法研究大鼠切牙中bFGF的表达。
结果
免疫组织化学结果显示大鼠切牙的成釉细胞、成牙本质细胞中有bFGF存在。Ⅱ组中bFGF的表达降低（P<0.01）。
结论
过量氟抑制bFGF的表达，影响牙上皮和牙间充质之间的相互作用，从而导致釉质脱矿。
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