Dannemann B R, Israelski D M, Leoung G S, McGraw T, Mills J, Remington J S
Research Institute, Palo Alto Medical Foundation Research Institute, CA 94301.
AIDS. 1991 Nov;5(11):1363-5. doi: 10.1097/00002030-199111000-00013.
In order to further characterize the pathogenesis of Toxoplasma gondii infection in patients with AIDS and AIDS-related complex (ARC), a cohort of HIV- and Toxoplasma-infected individuals were identified and prospectively followed. Four hundred and 10 HIV-infected individuals followed in the San Francisco General Hospital AIDS Clinic were screened for antibodies to Toxoplasma between November 1986 and November 1988. Of the 67 (16%) individuals seropositive for Toxoplasma antibodies, 33 (49%) were followed monthly for a mean duration of 7.5 months. One hundred and 11 follow-up blood samples were obtained in order to determine Toxoplasma serology and the incidence of parasitemia. In general, Toxoplasma immunoglobulin (Ig) G antibodies remained stable over time. Detection of Toxoplasma antigenemia and parasitemia was uniformly negative, including those specimens obtained from two individuals within 45 days of their developing toxoplasmic encephalitis.
为了进一步阐明艾滋病患者及艾滋病相关综合征（ARC）中弓形虫感染的发病机制，我们确定了一组感染HIV和弓形虫的个体并对其进行前瞻性随访。1986年11月至1988年11月期间，在旧金山综合医院艾滋病诊所对410名HIV感染者进行了弓形虫抗体筛查。在67名（16%）弓形虫抗体血清学阳性个体中，33名（49%）个体每月接受随访，平均随访时间为7.5个月。为了确定弓形虫血清学和血症发生率，共采集了111份随访血样。总体而言，弓形虫免疫球蛋白（Ig）G抗体随时间保持稳定。弓形虫抗原血症和血症的检测结果均为阴性，包括从两名发生弓形虫脑炎后45天内采集的标本。
