具有多个自旋的硝酰造影剂的修饰及其质子T(1)弛豫率

Modification of nitroxyl contrast agents with multiple spins and their proton T(1) relaxivity.

作者信息

Matsumoto Ken-Ichiro, Yakumaru Haruko, Narazaki Michiko, Nakagawa Hidehiko, Anzai Kazunori, Ikehira Hiroo, Ikota Nobuo

机构信息

Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan.

出版信息

Magn Reson Imaging. 2008 Jan;26(1):117-21. doi: 10.1016/j.mri.2007.05.009. Epub 2007 Aug 1.

DOI:10.1016/j.mri.2007.05.009

PMID:17683889

Abstract

The purpose of this study is to test the performance of multispin nitroxyl contrast agents in improving the sensitivity of MR detection for nitroxyl contrast agents. The relation between T(1) relaxivity and the number of paramagnetic centers in a molecule was investigated. Compound 1 is a single molecule of methoxycarbonyl-PROXYL (MC-PROXYL). Two and three MC-PROXYL molecules were chemically coupled to obtain Compounds 2 and 3, which have two and three nitroxyl spins in the molecule, respectively. A good linear relation, the slope of which increased depending on the number of nitroxyl spins in the molecule, was obtained between T(1)-weighted (fast low-angle shot) MR image contrast enhancement at 7 T and the concentration of nitroxyl contrast agents. T(1)-weighted MR image contrast enhancement and T(1) relaxivity levels of nitroxyl contrast agents were increased depending on the number of nitroxyl spins in the molecule. Multicoupling nitroxyl molecules can enhance the T(1)-weighted contrast effect while maintaining the quantitative behavior of the molecule for up to three spins.

摘要

本研究的目的是测试多自旋硝酰基造影剂在提高磁共振（MR）检测硝酰基造影剂灵敏度方面的性能。研究了分子中T(1)弛豫率与顺磁中心数量之间的关系。化合物1是甲氧基羰基 - PROXYL（MC - PROXYL）的单分子。将两个和三个MC - PROXYL分子进行化学偶联，分别得到化合物2和3，它们在分子中分别具有两个和三个硝酰基自旋。在7 T下，T(1)加权（快速小角度激发）MR图像对比度增强与硝酰基造影剂浓度之间获得了良好的线性关系，其斜率随分子中硝酰基自旋数量的增加而增大。硝酰基造影剂的T(1)加权MR图像对比度增强和T(1)弛豫率水平随分子中硝酰基自旋数量的增加而提高。多偶联硝酰基分子可以增强T(1)加权对比效果，同时在分子具有多达三个自旋时保持其定量行为。