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氮氧自由基作为磁共振氧化还原成像中的治疗诊断对比剂。

Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging.

机构信息

Quantitative RedOx Sensing Group, Department of Radiation Regulatory Science Research, National Institute of Radiological Sciences, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan.

Quantum RedOx Chemistry Group, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba-shi, Japan.

出版信息

Antioxid Redox Signal. 2022 Jan;36(1-3):95-121. doi: 10.1089/ars.2021.0110. Epub 2021 Jul 28.

DOI:10.1089/ars.2021.0110
PMID:34148403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8792502/
Abstract

assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as a normal tissue-selective radioprotector, is seen as being attractive on planning radiation therapy. redox imaging using nitroxyl radicals as redox-sensitive contrast agents has been developed to assess tissue redox status. Chemical and biological behaviors depending on chemical structures of nitroxyl radical compounds have been understood in detail. Polymer types of nitroxyl radical contrast agents and/or nitroxyl radical-labeled drugs were designed for approaching theranostics. Nitroxyl radicals as magnetic resonance imaging (MRI) contrast agents have several advantages compared with those used in electron paramagnetic resonance (EPR) imaging, while support by EPR spectroscopy is important to understand information from MRI. Redox-sensitive paramagnetic contrast agents having a medicinal benefit, that is, nitroxyl-labeled drug, have been developed and proposed. A development of suitable nitroxyl contrast agent for translational theranostic applications with high reaction specificity and low normal tissue toxicity is under progress. Nitroxyl radicals as redox-sensitive magnetic resonance contrast agents can be a useful tool to detect an abnormal tissue redox status such as disordered oxidative stress. . 36, 95-121.

摘要

基于循环氧化还原机制的氮氧自由基顺磁和反磁转化评估可以作为组织氧化还原状态的指标。氮氧自由基的氧化还原机制使其可用作正常组织选择性放射保护剂，这在规划放射治疗时被认为是有吸引力的。使用氮氧自由基作为氧化还原敏感对比剂的氧化还原成像是为了评估组织氧化还原状态而开发的。已经详细了解了氮氧自由基化合物的化学结构所依赖的化学和生物学行为。为了实现治疗诊断学，设计了氮氧自由基对比剂和/或氮氧自由基标记药物的聚合物类型。与用于电子顺磁共振（EPR）成像的那些相比，氮氧自由基作为磁共振成像（MRI）对比剂具有几个优点，而 EPR 光谱的支持对于理解来自 MRI 的信息很重要。已经开发出具有药用益处的氧化还原敏感顺磁对比剂，即氮氧标记药物。正在开发具有高反应特异性和低正常组织毒性的适合转化治疗应用的合适氮氧对比剂。作为氧化还原敏感磁共振对比剂的氮氧自由基可以成为检测异常组织氧化还原状态（如紊乱的氧化应激）的有用工具。

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