Thraenhart O, Kuwert E
Zentralbl Bakteriol Orig B. 1975 Dec;161(3):209-32.
"Gigasept" is a highly efficient chemical disinfectant on the basis of succine dialdehyde and form aldehyde. The virucidal capacity was assayed in the suspension test procedure with different representative RNA and DNA viruses with and without an envelope, such as polio wild virus type I, coxsackie virus type B 3, adeno virus type 3, herpes virus type ) and vaccinia virus. Parameter for disinfectant activity was the virus inactivation kinetic, i. e. interdependence of titer reduction vs. disinfectant concentration and disinfectant contact time. A "minimal disinfection" was defined as a greater than or equal to 99.9% virus inactivation. A "disinfection per definitionem" must gain a titer reduction of greater than or equal to 10(3) ID 50 and absence of virus. According to these criteria all virus strains were inactivated by Gigasept regardless of absence or presence of serum, which was tested in a concentration of 40% calf serum. Disinfection per definitionem was achieved with Gigasept concentrations of 3% after 60 min. or 5% after 30 min. except for enteroviruses. This group of viruses has to be disinfected with a 10% solution for 4 hours or with a 5% solution overnight. Gigasept, on the basis of these results, can be classified as a highly effective virucidal disinfectant. As to the hepatitis virus group however, no data so far are available. An enterovirus - disinfection procedure is recommended in hepatitis risk areas, as long as test systems for hepatitis viruses are not developed.
“Gigasept”是一种基于丁二醛和甲醛的高效化学消毒剂。采用悬浮试验程序，使用不同代表性的有包膜和无包膜的RNA及DNA病毒，如I型脊髓灰质炎野生病毒、B3型柯萨奇病毒、3型腺病毒、1型疱疹病毒和痘苗病毒，对其杀病毒能力进行了测定。消毒剂活性参数为病毒灭活动力学，即滴度降低与消毒剂浓度和消毒剂接触时间的相互关系。“最低消毒”定义为病毒灭活率大于或等于99.9%。“定义性消毒”必须使滴度降低大于或等于10(3) ID50且无病毒。根据这些标准，无论是否存在血清（以40%小牛血清浓度进行测试），Gigasept均可灭活所有病毒株。除肠道病毒外，使用3%的Gigasept溶液作用60分钟或5%的溶液作用30分钟可实现定义性消毒。该组病毒必须用10%的溶液消毒4小时或用5%的溶液过夜消毒。基于这些结果，Gigasept可归类为高效杀病毒消毒剂。然而，关于肝炎病毒组，目前尚无数据。在肝炎风险区域，只要尚未开发出肝炎病毒检测系统，建议采用肠道病毒消毒程序。
