Isidro-Llobet Albert, Just-Baringo Xavier, Alvarez Mercedes, Albericio Fernando
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028-Barcelona, Spain.
Biopolymers. 2008;90(3):444-9. doi: 10.1002/bip.20823.
In recent years, backbone protection has allowed the synthesis of complex peptidic sequences of high interest by preventing chain aggregation and aspartimides formation. Nevertheless, the backbone protectors currently used have some drawbacks: they are difficult to remove and show high steric hindrance. The new backbone protectors presented in this study (EDOTn and MIM) represent an improvement in both aspects.
近年来，主链保护通过防止链聚集和天冬酰胺形成，使得能够合成具有高度吸引力的复杂肽序列。然而，目前使用的主链保护剂存在一些缺点：它们难以去除且具有较高的空间位阻。本研究中提出的新型主链保护剂（EDOTn和MIM）在这两个方面均有所改进。
