[借助二丁酰-3',5'-单磷酸腺苷恢复培养的钾离子阻滞心肌细胞的自动收缩活性]
[Restoration of the automatic contractile activity of K+-arrested heart muscle cells in culture by means of dibutyryl-3', 5'-adenosine monophosphate].
作者信息
Warbanow W, Will-Shahab L, Wollenberger A
出版信息
Acta Biol Med Ger. 1975;34(9):1553-6.
PMID:176854
Abstract
Cultured myocardial cells of new-born rats which were arrested by 17.6-37.6 mM KCl regained their ability to contract spontaneously after perfusion with 8-10(-4)-4-10(-3) M dibutyryl cyclic AMP. This adrenaline-like action of DbcAMP is compatible with the notion that cyclic AMP is involved as a second messenger in the action of cyclic AMP-raising adrenergic agents on cardiac activity.
摘要
用17.6 - 37.6 mM氯化钾使新生大鼠培养的心肌细胞停搏后，在用8×10⁻⁴ - 4×10⁻³ M二丁酰环磷酸腺苷灌注后，它们恢复了自发收缩的能力。二丁酰环磷酸腺苷的这种类似肾上腺素的作用与环磷酸腺苷作为第二信使参与提高环磷酸腺苷的肾上腺素能药物对心脏活动作用的观点是一致的。
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