与凝血酶复合的生物合成磺基水蛭素的晶体结构。 - Suppr

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

作者信息

Liu Chang C, Brustad Eric, Liu Wenshe, Schultz Peter G

机构信息

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

J Am Chem Soc. 2007 Sep 5;129(35):10648-9. doi: 10.1021/ja0735002. Epub 2007 Aug 9.

DOI:10.1021/ja0735002

PMID:17685615

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2530905/

Abstract

摘要

相似文献

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

J Am Chem Soc. 2007 Sep 5;129(35):10648-9. doi: 10.1021/ja0735002. Epub 2007 Aug 9.

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.

Protein Sci. 1993 Oct;2(10):1630-42. doi: 10.1002/pro.5560021009.

pH dependence of the interaction of hirudin with thrombin.

Biochemistry. 1992 Feb 4;31(4):1168-72. doi: 10.1021/bi00119a028.

Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51).

J Mol Biol. 1992 Dec 20;228(4):1206-11. doi: 10.1016/0022-2836(92)90326-f.

Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin.

Biochemistry. 1992 May 19;31(19):4557-62. doi: 10.1021/bi00134a004.

Molecular basis for the inhibition of thrombin by hirudin.

Adv Exp Med Biol. 1993;340:35-49. doi: 10.1007/978-1-4899-2418-6_4.

Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.

Protein Sci. 1998 Feb;7(2):243-53. doi: 10.1002/pro.5560070203.

The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.

Protein Sci. 1997 Jul;6(7):1412-7. doi: 10.1002/pro.5560060705.

The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.

J Biol Chem. 1992 Sep 5;267(25):17670-8.

From natural to synthetic multisite thrombin inhibitors.

Biopolymers. 1999;51(1):19-39. doi: 10.1002/(SICI)1097-0282(1999)51:1<19::AID-BIP4>3.0.CO;2-G.

引用本文的文献

Functional analysis of protein post-translational modifications using genetic codon expansion.

Protein Sci. 2023 Apr;32(4):e4618. doi: 10.1002/pro.4618.

Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands.

Int J Mol Sci. 2021 Oct 6;22(19):10803. doi: 10.3390/ijms221910803.

Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review.

Front Pharmacol. 2021 Apr 16;12:660757. doi: 10.3389/fphar.2021.660757. eCollection 2021.

Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System.

Life (Basel). 2021 Apr 27;11(5):396. doi: 10.3390/life11050396.

Cell-free synthesis of the hirudin variant 1 of the blood-sucking leech Hirudo medicinalis.

Sci Rep. 2020 Nov 13;10(1):19818. doi: 10.1038/s41598-020-76715-w.

Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of .

PeerJ. 2019 Sep 30;7:e7716. doi: 10.7717/peerj.7716. eCollection 2019.

A molecular engineering toolbox for the structural biologist.

Q Rev Biophys. 2017 Jan;50:e7. doi: 10.1017/S0033583517000051.

Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.

Nat Chem Biol. 2017 Aug;13(8):845-849. doi: 10.1038/nchembio.2405. Epub 2017 Jun 12.

Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from .

J Biol Chem. 2017 Jul 28;292(30):12632-12642. doi: 10.1074/jbc.M117.788042. Epub 2017 Jun 7.

At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9):a023945. doi: 10.1101/cshperspect.a023945.

本文引用的文献

Recombinant expression of selectively sulfated proteins in Escherichia coli.

Nat Biotechnol. 2006 Nov;24(11):1436-40. doi: 10.1038/nbt1254. Epub 2006 Oct 29.

The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding.

FEBS J. 2006 Jan;273(1):159-69. doi: 10.1111/j.1742-4658.2005.05052.x.

Hirudin binding reveals key determinants of thrombin allostery.

J Biol Chem. 2005 Jul 22;280(29):26997-7003. doi: 10.1074/jbc.M502678200. Epub 2005 May 27.

A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.

J Biol Chem. 2004 Mar 26;279(13):13035-43. doi: 10.1074/jbc.M312430200. Epub 2004 Jan 13.

Hirudin as alternative anticoagulant--a historical review.

Semin Thromb Hemost. 2002 Oct;28(5):405-14. doi: 10.1055/s-2002-35292.

Structure-based design of novel potent nonpeptide thrombin inhibitors.

J Med Chem. 2002 Apr 25;45(9):1757-66. doi: 10.1021/jm0109513.

Current status of the anticoagulant hirudin: its biotechnological production and clinical practice.

Appl Microbiol Biotechnol. 2001 Dec;57(5-6):606-13. doi: 10.1007/s00253-001-0856-9.

Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.

J Mol Biol. 2001 Aug 17;311(3):549-55. doi: 10.1006/jmbi.2001.4872.

Identification and three-dimensional structural analysis of nine novel mutations in patients with prothrombin deficiency.

Thromb Haemost. 2000 Dec;84(6):989-97.

The molecular environment of the Na+ binding site of thrombin.

Biophys Chem. 1997 Jan 31;63(2-3):185-200. doi: 10.1016/s0301-4622(96)02227-2.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献