决明孪胺A和B，来自暹罗决明的新型抗疟生物碱。

Cassiarins A and B, novel antiplasmodial alkaloids from Cassia siamea.

作者信息

Morita Hiroshi, Oshimi Shiori, Hirasawa Yusuke, Koyama Koichiro, Honda Toshio, Ekasari Wiwied, Indrayanto Gunawan, Zaini Noor Cholies

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.

出版信息

Org Lett. 2007 Aug 30;9(18):3691-3. doi: 10.1021/ol701623n. Epub 2007 Aug 9.

DOI:10.1021/ol701623n

PMID:17685627

Abstract

Two novel alkaloids with an unprecedented tricyclic skeleton, cassiarins A (1) and B (2), have been isolated from the leaves of Cassia siamea, and the structures were elucidated on the basis of spectroscopic data. Cassiarin A (1) showed a potent antiplasmodial activity.

摘要

从暹罗决明的叶子中分离出了两种具有前所未有的三环骨架的新型生物碱，决明素A（1）和决明素B（2），并根据光谱数据阐明了其结构。决明素A（1）显示出强大的抗疟活性。