Waller D G, Usman F, Renwick A G, Macklin B, George C F
Clinical Pharmacology Group, University of Southampton, Southampton General Hospital.
Br J Clin Pharmacol. 1991 Dec;32(6):771-3.
To investigate possible mechanisms of levodopa-induced gastric stasis, we have studied the effect of other amino acids on gastric emptying. The large neutral amino acid tryptophan delays gastric emptying in the dog at molar concentrations below those required to stimulate duodenal osmoreceptors. In healthy volunteers, we have shown that neither tryptophan nor the small neutral amino acid glycine delayed gastric emptying when given in concentrations similar to those of levodopa which produce gastric stasis. The study suggests that levodopa does not inhibit gastric emptying by an effect on duodenal amino acid receptors or via osmoreceptors.
为研究左旋多巴诱发胃潴留的可能机制，我们研究了其他氨基酸对胃排空的影响。在犬中，大中性氨基酸色氨酸在低于刺激十二指肠渗透压感受器所需摩尔浓度时可延迟胃排空。在健康志愿者中，我们发现，给予与产生胃潴留的左旋多巴浓度相似的色氨酸或小中性氨基酸甘氨酸时，二者均不会延迟胃排空。该研究提示，左旋多巴并非通过作用于十二指肠氨基酸受体或经由渗透压感受器来抑制胃排空。
