Watanabe I, Kasai M, Watanuki T, Amano S
Acta Hepatogastroenterol (Stuttg). 1975 Jun;22(3):158-64.
Malignant mixed tumor of the liver seen in a 4 year old girl was reported. Progressive hepatomegaly, jaundice, anemia, and extraordinarily high level of serum total cholesterol were noted clinically. Postmortem examination had disclosed that most part of the tumor was occupied by fibrosarcomatous cell growth admixed with rhabdomyosarcomatous component. In addition, carcinomatous component was distinctly recognized in a restricted part of the liver tumor. Previous reports on malignant mixed tumor of the liver were reviewed and it was emphasized that the histological diagnosis of malignant hepatic mixed tumor must be cautiously followed Edmondson's criteria; which requires existence of both epithelial and mesenchymal components of neoplastic nature and malignancy of either or both components in a hepatic tumor.
报告了一名4岁女孩所患的肝脏恶性混合瘤。临床上可见进行性肝肿大、黄疸、贫血以及血清总胆固醇水平异常升高。尸检发现肿瘤的大部分被纤维肉瘤细胞生长占据,并混有横纹肌肉瘤成分。此外,在肝脏肿瘤的局限部位可明确识别出癌成分。回顾了以往关于肝脏恶性混合瘤的报告,并强调对肝脏恶性混合瘤的组织学诊断必须谨慎遵循埃德蒙森标准;该标准要求肝脏肿瘤中存在肿瘤性的上皮和间充质成分,且其中一种或两种成分具有恶性特征。