颌骨中心性巨细胞肉芽肿中的基质肌成纤维细胞无法区分非侵袭性和侵袭性病变。
Stromal myofibroblasts in central giant cell granuloma of the jaws cannot distinguish between non-aggressive and aggressive lesions.
作者信息
Vered Marilena, Nasrallah Warda, Buchner Amos, Dayan Dan
机构信息
Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
J Oral Pathol Med. 2007 Sep;36(8):495-500. doi: 10.1111/j.1600-0714.2007.00541.x.
OBJECTIVE
To investigate correlations between myofibroblast density (MFD) and biological behavior of a large series of non-aggressive and aggressive central giant cell granuloma lesions (CGCGs).
METHODS
Twenty-four non-aggressive and 17 aggressive lesions were immunohistochemically stained with alpha smooth muscle actin. MFD was assessed using the point counting method in the lesions' core tissue and in control areas that consisted of non-involved, connective tissue surrounding the lesion.
RESULTS
All CGCGs contained myofibroblasts among the stromal cells. No significant differences were found in the mean percentage of MFD (%MFD) of non-aggressive (20.8 +/- 15.7%) and aggressive (23.7 +/- 22.9%) lesions (P > 0.05) or in the mean %MFD of the respective control areas (1.4 +/- 2.2% and 1.7 +/- 4.1%; P > 0.05). The mean core tissue %MFD of both lesion types was significantly higher than that of the control areas (P < 0.001).
CONCLUSION
Myofibroblasts were an integral component of CGCG stromal cells, but their density could not distinguish between non-aggressive and aggressive lesions.
目的
研究大量非侵袭性和侵袭性中央巨细胞肉芽肿病变（CGCG）中肌成纤维细胞密度（MFD）与生物学行为之间的相关性。
方法
对24例非侵袭性病变和17例侵袭性病变进行α平滑肌肌动蛋白免疫组织化学染色。采用点计数法评估病变核心组织及由病变周围未受累结缔组织组成的对照区域的MFD。
结果
所有CGCG的基质细胞中均含有肌成纤维细胞。非侵袭性病变（20.8±15.7%）和侵袭性病变（23.7±22.9%）的MFD平均百分比（%MFD）之间未发现显著差异（P>0.05），各自对照区域的平均%MFD也无显著差异（1.4±2.2%和1.7±4.1%；P>0.05）。两种病变类型的核心组织平均%MFD均显著高于对照区域（P<0.001）。
结论
肌成纤维细胞是CGCG基质细胞的一个组成部分，但其密度无法区分非侵袭性和侵袭性病变。
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