Avvisati G, Mele A, Stazi M A, Vegna M L, Pasquini P, Mandelli F
Dipartimento di Biopatologia Umana, Università La Sapienza, Italy.
Ann Oncol. 1991 Jun;2(6):405-8. doi: 10.1093/oxfordjournals.annonc.a057974.
This retrospective epidemiologic study on 256 cases of Acute Promyelocytic Leukemia (APL) observed in 20 Italian hematology centers between 1980 and 1988 demonstrated that APL is different from the other acute non-lymphocytic leukemias (ANLL). The male/female ratio was 0.9; median age at diagnosis was 40 years (with 80% of patients between 15 and 54 years of age). The minimal annual incidence of APL in Italy per 1,000,000 inhabitants was estimated to be 0.6; an increased incidence was observed in spring and in autumn. The overall median survival duration of APL patients was 12.6 months. From an epidemiological point of view APL is a distinctive subtype of ANLL.
这项对1980年至1988年间在20个意大利血液学中心观察到的256例急性早幼粒细胞白血病（APL）患者进行的回顾性流行病学研究表明，APL与其他急性非淋巴细胞白血病（ANLL）不同。男女比例为0.9；诊断时的中位年龄为40岁（80%的患者年龄在15至54岁之间）。据估计，意大利每100万居民中APL的最低年发病率为0.6；春季和秋季发病率有所上升。APL患者的总体中位生存期为12.6个月。从流行病学角度来看，APL是ANLL的一个独特亚型。
