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3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.

作者信息

Hosoda Shinnosuke, Hashimoto Yuichi

机构信息

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

出版信息

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5414-8. doi: 10.1016/j.bmcl.2007.07.039. Epub 2007 Jul 31.

DOI:10.1016/j.bmcl.2007.07.039
PMID:17686629
Abstract

We designed and synthesized novel type 1 5alpha-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5alpha-reductase inhibitor with the IC(50) value of 0.84 microM.

摘要

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