Mourad Pierre D, Roberts Frank A, McInnes Christopher
Department of Neurological Surgery, University of Washington Dental School, Seattle, Washington, USA.
Compend Contin Educ Dent. 2007 Jul;28(7):354-8.
Proving that an idea has merit for further investigation is one of the earliest steps in product development. This proof of concept can be effectively studied in a dynamic, multidisciplinary environment where ideas can be quickly tested in a manner related to final product use. In this article, the authors demonstrate the fecundity of a multidisciplinary environment by reviewing their early work that shows that ultrasound could be added to a power toothbrush to enhance the removal of dental plaque bacteria. They hypothesized that sonic brush head motion would generate bubbles in a dentifrice so that ultrasound beamed into that slurry would cause those bubbles to expand and contract in a manner that would dislodge the plaque bacteria adherent to the tooth surfaces. In this work, Streptococcus mutans bacteria adherent to various surfaces was used as a model of dental plaque on human teeth. Prototype power toothbrushes were created using commercially available and custom components so that the ultrasound and sonic processes could be individually modified and applied. Research demonstrated that the combination of sonic and ultrasound processes could synergistically remove S mutans biofilm. This finding established the proof of concept that eventually led to the development of a power toothbrush that uses both ultrasound and sonic activity.
证明一个想法值得进一步研究是产品开发的早期步骤之一。这种概念验证可以在一个动态的、多学科的环境中有效地进行研究,在这个环境中,想法可以以与最终产品使用相关的方式快速得到测试。在本文中,作者通过回顾他们早期的工作来展示多学科环境的成效,这些工作表明,可以在电动牙刷中加入超声波,以增强对牙菌斑细菌的清除。他们推测,声波刷头的运动会在牙膏中产生气泡,因此,照射到该牙膏糊中的超声波会使这些气泡以一种能去除附着在牙齿表面的牙菌斑细菌的方式膨胀和收缩。在这项工作中,附着在各种表面的变形链球菌被用作人类牙齿上牙菌斑的模型。使用市售部件和定制部件制作了电动牙刷原型,以便可以分别对超声波和声波过程进行修改和应用。研究表明,声波和超声波过程的结合可以协同去除变形链球菌生物膜。这一发现确立了概念验证,最终促成了一款同时利用超声波和声波活动的电动牙刷的开发。