范可尼贫血患儿的口腔和牙齿表现

Oral and dental findings in children with Fanconi anemia.

作者信息

Tekcicek Meryem, Tavil Betul, Cakar Asli, Pinar Asli, Unal Selma, Gumruk Fatma

机构信息

Department of Pediatric Dentistry, Hacettepe University Faculty of Medicine.

出版信息

Pediatr Dent. 2007 May-Jun;29(3):248-52.

PMID:17688024

Abstract

PURPOSE

The purpose of this study was to investigate the oral and dental findings in children with Fanconi anemia (FA).

METHODS

The study included 26 FA patients who came to the hospital (Hacettepe University Faculty of Medicine, Pediatric Hematology Unit) from the central region of Anatolia (17 [65%] mole, 9 [35%] female; mean age = 10.0 +/- 5.2 years (range = 2-18; median = 9 years]). Oral and radiological examinations and salivary collection were performed at the Department of Pediatric Dentistry of Hacettepe University Faculty of Dentistry.

RESULTS

Among 26 FA children: (a) 16 (62%) had never visited a dentist; (b) 6 (23%) had visited a dentist once; and (c) 4 (15%) had visited a dentist regularly. Furthermore: (a) only 5 children (19%) brushed their teeth regularly; (b) 7 (27%) had never brushed their teeth previously; and (c) the other 14 (54%) had brushed their teeth rarely. The prevalence of dental caries was 35% in this study's patients. Gingival examination revealed that 9 (35%) children had gingivitis and the other 17 (65%) had normal gingival health status. Examination of the oral cavity revealed that: (a) 3 children (12%) had a coated tongue; and (b) 1 (4%) had papillary atrophy. No leukoplakia or other precancerous lesion was detected in this patient group. Salivary flow rate was less than 0.7 ml/minute in 56% of the patients. No patients had a salivary pH less than 5. Salivary buffering capacity of less than 5, however, was detected in 5 patients (33%). Radiological evaluation revealed that the most common congenital dental abnormalities were: (1) microdontia (44%); (2) congenitally missing teeth (26%); (3) transposition (9%); and (4) supernumerary teeth (4%).

CONCLUSION

These results demonstrate that poor oral hygiene, dental decay, gingivitis, and congenital dental abnormalities--including generalized microdontia, supernumerary teeth, transposition, and congenitally missing teeth--are common oral and dental findings in this group of Turkish children with Fanconi anemia.

摘要

目的

本研究旨在调查范可尼贫血（FA）患儿的口腔和牙齿情况。

方法

该研究纳入了26例来自安纳托利亚中部地区的FA患者（他们来到哈杰泰佩大学医学院儿科血液科就诊）（17例[65%]为男性，9例[35%]为女性；平均年龄 = 10.0±5.2岁（范围 = 2 - 18岁；中位数 = 9岁））。在哈杰泰佩大学牙科学院儿科牙科进行了口腔和放射学检查以及唾液采集。

结果

在26例FA患儿中：（a）16例（62%）从未看过牙医；（b）6例（23%）看过一次牙医；（c）4例（15%）定期看牙医。此外：（a）只有5名儿童（19%）有规律地刷牙；（b）7名（27%）以前从未刷过牙；（c）另外14名（54%）很少刷牙。本研究患者的龋齿患病率为35%。牙龈检查显示，9名（35%）儿童患有牙龈炎，另外17名（65%）牙龈健康状况正常。口腔检查发现：（a）3名儿童（12%）舌苔增厚；（b）1名（4%）有乳头萎缩。该患者组未检测到白斑或其他癌前病变。56%的患者唾液流速低于0.7毫升/分钟。没有患者的唾液pH值低于5。然而，5名患者（33%）的唾液缓冲能力低于5。放射学评估显示，最常见的先天性牙齿异常为：（1）小牙畸形（44%）；（2）先天性缺牙（26%）；（3）牙齿异位（9%）；（4）多生牙（4%）。