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α-肾上腺素能受体在泌尿系统疾病治疗中的作用。

The role of alpha-adrenoreceptors in the treatment of urological diseases.

作者信息

Romics Imre

机构信息

Department of Urology, Semmelweis University, Ulloi street 78/B., Budapest H-1082, Hungary.

出版信息

Neurochem Int. 2007 Oct;51(5):328-31. doi: 10.1016/j.neuint.2007.05.023. Epub 2007 Jun 28.

Abstract

One of the most important clinical pharmacological invention in the last decades the role of adrenoreceptors in urological disease. The disorders of emptying the bladder are associated to the urology. Plant extracts efficacy is low, indicated only in mild symptoms, surgery has to be performed in advanced cases. Recognise, discovering the role of adrenoreceptors in the prostate, bladder neck has changed the treatment of benign prostatic hyperplasia. Relieving the muscle tension leads to a better urinary flow, decreased residual urine and less complaints. Combination with 5alpha-reductase inhibitor a better results can be achieved. The inflammation in prostate is a frequent disease of all age of males. Spasm of the bladder neck maintains the complaints additional alpha-blocker treatment combined with antibiotics, anti-inflammatory drugs are the best choice to cure the patients. Alpha-adrenergic receptor can be found in the lower part of ureter as well. To promote the spontaneous expulsion of lower ureter stones, or fragments after ESWL (extracorporal shock wave lithotripsy) the alpha-blockers are highly recommended.

摘要

过去几十年最重要的临床药理学进展之一是肾上腺素能受体在泌尿系统疾病中的作用。膀胱排空障碍与泌尿外科相关。植物提取物疗效较低,仅适用于轻度症状,晚期病例则需进行手术。认识到、发现肾上腺素能受体在前列腺、膀胱颈中的作用改变了良性前列腺增生的治疗方法。缓解肌肉紧张可使尿流改善、残余尿量减少且不适症状减轻。与5α-还原酶抑制剂联合使用可取得更好的效果。前列腺炎症是所有年龄段男性的常见疾病。膀胱颈痉挛会加重不适症状,联合使用α受体阻滞剂、抗生素和抗炎药物是治疗患者的最佳选择。α-肾上腺素能受体在输尿管下段也有发现。为促进输尿管下段结石或体外冲击波碎石(ESWL)后结石碎片的自行排出,强烈推荐使用α受体阻滞剂。

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