Rebmann Vera, Wagner Stefan, Grosse-Wilde Hans
Institut für Immunologie, Universitätsklinikum Essen, Virchowstr. 171, D-45122 Essen, Germany.
Semin Cancer Biol. 2007 Dec;17(6):422-9. doi: 10.1016/j.semcancer.2007.06.010. Epub 2007 Jun 28.
Both, the expression of HLA-G (a non-classical HLA class I molecule) and the loss of classical HLA class I molecules enable tumor cells to evade from immunosurveillance of the host. Whereas HLA-G down-modulates the immune functions of all cells participating in the immune defence mechanisms, defects on HLA class I expression result in the resistance of tumor cells to cytotoxic T lymphocytes attacks. This contribution reviews the HLA-G expression pattern in malignant melanoma lesions, its correlation to the loss of classical HLA class I antigens, and new aspects of HLA-G regulation.
HLA-G（一种非经典的I类HLA分子）的表达以及经典I类HLA分子的缺失，均可使肿瘤细胞逃避宿主的免疫监视。HLA-G可下调参与免疫防御机制的所有细胞的免疫功能，而I类HLA表达缺陷则导致肿瘤细胞对细胞毒性T淋巴细胞攻击产生抗性。本文综述了恶性黑色素瘤病变中HLA-G的表达模式、其与经典I类HLA抗原缺失的相关性以及HLA-G调控的新方面。
