Cabestre F A, Lefebvre S, Moreau P, Rouas-Friess N, Dausset J, Carosella E D, Paul P
Service de Recherches en Hémato-immunologie, CEA/DRM/DSV, Hôpital Saint-Louis, Centre Hayem, 1 avenue Claude Vellefaux, Paris, Cedex 10, 75475, France.
Semin Cancer Biol. 1999 Feb;9(1):27-36. doi: 10.1006/scbi.1998.0104.
The non-classical class I antigen HLA-G has been shown to play a role in foeto-maternal tolerance. It interacts with inhibitory receptors to down-regulate natural killer and T cell cytotoxic functions. We here report our investigations on HLA-G expression in melanoma cells and its implication in the induction of immune tolerance to tumours. We provide the first evidence that both malignant human melanoma cell lines and ex vivo biopsies can exhibit high levels of HLA-G transcription with differential HLA-G isoform transcription and protein expression patterns. We further demonstrated that melanoma cells that express HLA-G inhibit NK cytolysis. We thus propose that HLA-G expression may impede the elimination of malignant cells by anti-tumour immune effector cells, constituting a newly described mechanism by which tumour cells may evade immunosurveillance.
非经典I类抗原HLA-G已被证明在胎儿-母体耐受中发挥作用。它与抑制性受体相互作用，下调自然杀伤细胞和T细胞的细胞毒性功能。我们在此报告我们对黑色素瘤细胞中HLA-G表达及其在诱导肿瘤免疫耐受中的意义的研究。我们提供了首个证据，即恶性人类黑色素瘤细胞系和离体活检组织均可表现出高水平的HLA-G转录，且具有不同的HLA-G异构体转录和蛋白质表达模式。我们进一步证明，表达HLA-G的黑色素瘤细胞可抑制自然杀伤细胞的细胞溶解作用。因此，我们提出HLA-G表达可能会阻碍抗肿瘤免疫效应细胞对恶性细胞的清除，这构成了一种新描述的肿瘤细胞逃避免疫监视的机制。
