Saneto Russell P, Sotero de Menezes Marcio
Division of Pediatric Neurology, Children's Hospital and Regional Medical Center/University of Washington, Seattle, Washington 98105, USA.
J Child Neurol. 2007 May;22(5):631-4. doi: 10.1177/0883073807303220.
Early infantile epileptic encephalopathy, or Ohtahara syndrome, is characterized by tonic spasms and a suppression-burst pattern on the electroencephalography (EEG). The EEG demonstrates a suppression-burst pattern during waking and sleeping states that often evolves into hypsarrhythmia and followed later by a diffuse slow spike-wave pattern. In other patients, the EEG evolves into focal spike discharges or multiple independent spike foci. We report a 5-year-old girl with Ohtahara syndrome that persistently demonstrated tonic spasms and suppression-burst on multiple EEGs. Over her lifetime, neither hypsarrhythmia nor diffuse slow spike-wave pattern were seen. This suggests that in Ohtahara syndrome, a suppression-burst pattern can persist over a long period of time.
早期婴儿型癫痫性脑病，即大田原综合征，其特征为强直性痉挛以及脑电图（EEG）上的抑制-爆发模式。脑电图在清醒和睡眠状态下均显示出抑制-爆发模式，这种模式常演变为高度失律，随后又会出现弥漫性慢棘波模式。在其他患者中，脑电图会演变为局灶性棘波放电或多个独立的棘波灶。我们报告了一名患有大田原综合征的5岁女孩，其多次脑电图检查持续显示强直性痉挛和抑制-爆发模式。在她的一生中，既未出现高度失律，也未出现弥漫性慢棘波模式。这表明在大田原综合征中，抑制-爆发模式可能会长期持续存在。
